The iSimangaliso coastline has attracted many avid fishermen to its shores. The lakes and ocean are teeming with fish. Sodwana Bay and St Lucia are particularly favoured as fishing destinations. The warm waters off the coast are a result of of the Agulhas current coming in close to the shore. A continental shelf lying within 1-3km of the shore is responsible for the deep trenches that attract game fish.
Anglers and skippers are required to abide by strict rules and regulations. The use of nets (unless under licence) and lights are prohibited. Vertical jigging is not permitted anywhere in the Park. Spear fishing is permissible to a licence holder on the coast except in the Marine Protected Areas.